We offer a range of skin-regenerative polynucleotide treatments at Dermal Health. Their purpose? To improve the skin’s hydration, elasticity, and firmness through tissue repair and increased cell turnover.

polynucleotide therapy


We offer a range of skin-regenerative polynucleotide treatments at Dermal Health. Their purpose? To improve the skin’s hydration, elasticity, and firmness through tissue repair and increased cell turnover.

Treatment Type


Results Last

6-12 Months

Treatment Length

10-20 Minutes


24 Hours

Introduction to Polynucleotides

Polynucleotides are naturally occurring molecules made up of long chains of nucleotides, the basic building blocks of DNA and RNA. When used in dermatological treatments, polynucleotides work to promote skin tissue regeneration and the restoring of skin tone and elasticity.


Polynucleotides also work towards the repair of damaged skin and the enhancing of overall skin health by stimulating cell growth and improving the extracellular matrix. A Polynucleotide treatment involves injecting these molecules into the skin areas of the face, triggering skin regeneration and improvements in skin texture and firmness.


Unlike hyaluronic acid skin boosters, polynucleotides stimulate natural DNA repair mechanisms, making them a suitable innovative treatment for various skin conditions and sensitive skin types. They come with minimal downtime.

Polynucleotide Benefits

  • Hydration: Boosts skin moisture levels, leading to a plumper, more youthful appearance.
  • Elasticity: Enhances skin elasticity by stimulating collagen production.
  • Firmness: Improves skin firmness through cellular regeneration.
  • Tissue Repair: Aids in the repair of damaged skin tissue and accelerates healing processes.
  • Increased Cell Turnover: Promotes the shedding of dead skin cells and the growth of new ones, resulting in a fresher complexion.
  • Antioxidant properties
  • Skin hydration
  • General regeneration of the skin

The Dermal Health Range Of Polynucleotides

Vitaran I and Vitaran iI

Vitaran is a leading polynucleotide injectable range designed to deeply hydrate and revitalise the skin. Created using 100% purified fragments of salmon DNA, Vitaran is renowned for its exceptional quality and effectiveness. This treatment focuses on enhancing the skin’s natural healing processes, giving improvements in both texture and tone. 

Vitaran I is particularly effective for its anti-ageing properties in reducing the appearance of periocular wrinkles (including the under-eye area), and improving the quality of the skin in that area. It also offers anti-inflammatory benefits, aids in skin rejuvenation and repair, and stimulates the production of collagen and elastin.

 Vitaran II can be used in the following areas:

  • Neck
  • Hands
  • Décolleté
  • Face

Key Benefits of Vitaran:

  • Deep Hydration: Enhances skin moisture levels, leading to a plumper appearance.
  • Skin Rejuvenation: Stimulates collagen and elastin production for improved skin texture and tone.
  • Anti-Inflammatory: Reduces inflammation, promoting a calmer skin environment.
  • Cellular Repair: Works on a cellular level to repair and rejuvenate the skin.
  •  Vitaran is CE-marked, signifying that it has been rigorously evaluated and meets the stringent safety, health, and environmental protection standards set by the European Union. 

NucleoFill Soft

NucleoFill Soft is a lightweight polynucleotide injectable designed to refine the appearance of fine lines, wrinkles, and volume loss. This treatment is safe for all skin types and can be combined with other treatments for enhanced results.


NucleoFill Soft works by stimulating collagen and elastin production, making the skin appear firmer and more elastic. It also helps renew and refresh the skin, providing patients with a brighter and firmer appearance.

Key Benefits of NucleoFill Soft

  • Fine Line Reduction: Targets and smooths out fine lines and wrinkles.
  • Volume Restoration: Helps restore lost volume for a more youthful look.
  • Skin Renewal: Promotes the renewal of skin cells, resulting in a fresher complexion.
  • Combination Therapy: Polynucleotides can be used alongside other treatments for comprehensive skin rejuvenation.
  • Improve skin elasticity and hydration

Treatment Areas for Nucleofill Soft

  • Small scars
  • Very thin lines
  • Bio-restructuration of deep tissues
  • Re-densification of the dermo-epidermal tissue
  • Improvement of superficial wrinkles without the use of fillers
  • Skin conditions on the face and body such as Crepey Skin

Anti-Ageing Injections

Both Vitaran and NucleoFill Soft represent the latest in aesthetic innovation, offering patients significant benefits for skin rejuvenation and anti-ageing when compared to other available treatments. Polynucleotides are ideal for patients looking to enhance their skin’s natural regenerative capabilities and achieve a more youthful, radiant appearance.

Why Choose Dermal Health?

  • Expertise: With years of specialised training and hands-on experience, Úna is extremely well-versed in the latest advancements in polynucleotide therapy and innovative treatments that use polynucleotide injections.
  • Extended range of treatments for skin rejuvenation: This means that you, the patient, will not be limited to one type or brand of treatment for your skin concerns.
  • Patient-Centered Philosophy: Your comfort and satisfaction are our top priorities. We strive to create a welcoming, supportive environment where you feel valued and cared for throughout your treatment journey. 
  • We always work from a customised treatment plan. 

Polynucleotide FAQs

Yes, polynucleotide treatments are generally safe and well-tolerated. They are derived from natural sources and have been extensively tested for their safety and efficacy for use in skin treatments and medical applications.

Side effects from polynucleotides are typically minimal and may include mild redness, swelling, or irritation at the injection site. These effects usually subside quickly. Polynucleotides are suitable for various skin types, even sensitive skin but, as with any treatment, there is always a chance of skin reaction.

Polynucleotide treatments are generally suitable for various skin types, including sensitive skin. Patients with specific skin concerns, conditions, or allergies should mention this and discuss during consultation to ensure compatibility.

Polynucleotides can also be used for tissue regeneration and restoring skin tone and elasticity, making them potentially beneficial for scar treatment. A consultation would be the best place to start for specific advice as to the best course of action for scarring.

Yes, polynucleotides can be effective on stretch marks. As with scarring, a consultation would be best to allow for exact advice on your particular case.

Your Skin Health and Appearance

We want all out patients to get the absolute best from our innovative treatments as well as being completely informed as to their options.

During your consultation we will provide an introduction to polynucleotides and how they trigger regeneration in the skin. A customised treatment plan will be created.  All your options with be thoroughly covered. If you have questions and are not quite ready to book in for a consultation please feel free to use our contact form.

Please bear in mind that the effects of polynucleotide treatments can vary depending on individual skin conditions.

Meet your Practitioner, Úna Jefford

Our medical director, Úna has an extensive medical knowledge combined with an ongoing curiosity to learn about the latest trends. Úna is known for her warm and personal approach. Dermal Health is quickly becoming London’s number-one aesthetic clinic.

Una Jefford